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STROMECTOL* (Ivermectin) is a semisynthetic, order stromectol anthelmintic agent for oral administration. Ivermectin is derived from the avermectins,stromectol for body lice, a class of highly active broad-spectrum, anti-parasitic agents isolated from the fermentation products of Streptomyces avermitilis. Ivermectin is a mixture containing at least 90% 5-O-demethyl-22,23-dihydroavermectin A1a and less than 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a, stromectol and alcohol, generally referred to as 22,23-dihydroavermectin B1a and B1b, or H2B1a and H2B1b, respectively. The respective empirical formulas are C48H74O14 and C47H72O14, with molecular weights of 875.10 and 861.07, respectively. The structural formulas are: Component B1a, R = C2H5 Component B1b, R = CH3 Ivermectin is a white to yellowish-white, is stromectol, nonhygroscopic, crystalline powder with a melting point of about 155°C. It is insoluble in water but is freely soluble in methanol and soluble in 95% ethanol. STROMECTOL is available in 3-mg tablets containing the following inactive ingredients: microcrystalline cellulose, pregelatinized starch, stromectol lice, magnesium stearate, butylated hydroxyanisole, and citricacid powder (anhydrous).

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